Mesothelioma Victims

Mesothelioma victims suffer from this rare cancer which is also known as asbestos disease because it is usually caused by exposure to asbestos, either directly or indirectly.

The disease is difficult to diagnose because all of the obvious symptoms can be caused by other less serious medical problems. There are screening methods which can help but no generally accepted screening approach yet. Most mesothelioma victims die within about a year and a half of knowing they have the disease, not because it progresses rapidly but because the disease is often only diagnosed in the late stages.

It is a disease which most commonly affects the lining of the lungs. Symptoms can develop several decades after the exposure to asbestos and the exposure can be indirect such as when washing the clothes of someone working with asbestos. Another complicating factor is that the amount of exposure to asbestos does not correlate well with the likelihood of becoming a victim of the disease.

Treatment usually prolongs the life of someone with mesothelioma. Combination treatments which often consist of radical surgery followed by both chemotherapy and radiation treatment have shown better results than any one treatment alone.

For all the above reasons, it is important for anyone who might be suffering from the disease to find the very best specialist they can, for diagnosis and treatment. The treatment can be expensive, sometimes totaling around a million dollars.

Most victims apply for compensation for the disease, and the claims can be considerable, sometimes exceeding tens of millions of dollars. For this reason there are specialist legal practitioners in countries where the disease is most common, including USA, UK, Canada ad Australia.

Mesothelioma victims can now get support from a number of sources including information and support groups online, cancer centers and specialists.

Article Source: http://EzineArticles.com/?expert=Thomas_Goldman

Mesothelioma Prognosis

A brief on Mesothelioma
A whopping 2,000 to 3,000 new cases of mesothelioma is on the rise in United States of America. Mesothelioma is a rare form of cancer and it is an aftereffect of the asbestos exposure. The cancerous cells tend to destroy the mesothelium, which is a protective sac that holds the internal organs of the body. Initially, pleura or peritoneum are affected and then it spreads to the other parts of the body. It is a fatal disease and the survival time of the victim is almost one year from the time of diagnosis depending on the treatment and other contributing factors.

What is mesothelioma prognosis?
Prognosis for mesothelioma is solely dependent on the merit of diagnosis and the treatment. If treatment is provided with much delay then the survival chance of the victim grows slimmer. Then again, survivability depends heavily on factors like treatment, type of mesothelioma as well as patients health and morale. The stage of the disease during diagnosis is the most crucial factor that decides the prognosis and the minimum survival expectancy of the victim. But disappointingly, mesothelioma unlike other cancers is somewhat difficult to stage. This is because the symptoms of mesothelioma are non-specific due to which the cells are already matured at the time of diagnosis.

What are the determining factors that lead to prognosis?
The early detection of the disease is imperative for pursuing any kind of treatment. The location and size of the cancer, response of the cancer to the treatment, the extent to which the cancer has spread, what impression does the cells give under the microscope and the patients age are some of the contributing factors that determine prognosis. It should be pointed out that diagnosis of the disease is not a child’s play. Further more it becomes all the very more difficult because of the deceptive nature of the subtle symptoms of mesothelioma. Like for example, if you are coughing and you might never know that you have contracted the disease unless and until your doctor clarifies it all by providing a mesothelioma prognosis.

Do you know about the mesothelioma treatment options?
Amongst the staging systems the oldest of them all is the Butchart system, based on the extent of mass, primary tumor and segregates the cancer into four stages. The TNM system is a more recent one while the Brigham system is the latest. It uses resectability and lymph node involvement for staging mesothelioma. The traditional kinds of treatments are also prevalent in case of malignant mesothelioma. Radiation therapy exercises high-energy X-rays to eradicate cancer cells while chemotherapy does it through use of drugs. Immunotherapy helps to strengthen the immune system; photodynamic therapy uses light energy while the genetic therapy resurrects the inherent genetic defects of the patient to fight the disease.

The process of removing fluid from the chest is known as thoracentesis while fluid reduction from the abdomen is known as paracentesis. Conventional surgeries and effective drugs like L-NDDP or Platar, Endostatin and Lovastatin somewhat come to the rescue of the victims of mesothelioma. The surgical removal of a part of the chest or the abdominal lining is called pleurectomy and if the lung is removed, then the operation will be termed as pneumonectomy.

Summary:
Prognosis for mesothelioma is solely dependent on the merit of diagnosis and the treatment. If treatment is provided with much delay then the survival chance of the victim grows slimmer.

How do you treat pericardial mesothelioma ?

Of all the cancers caused by asbestos dust (mesothelioma), pericardial mesothelioma is the most rare, accounting for a fraction of all cases (5%). It is a cancer that grows on the pericardium (the lining of the heart). This is a delicate ‘film’, and any infection on the pericardium can have deadly consequences.

Once an individual has been diagnosed with pericardial mesothelioma they are offered three different treatment options. These are radiation, surgery and chemotherapy. Pericardial mesothelioma is extremely difficult to treat (due to the intricacies involved in removing the tumours from the pericardium), and a patient’s chances of survival are slim. All three methods have a poor success rate mainly due to the fact that pericardial mesothelioma is detected in the mature stages of development. (The reason for this is because in the early stages of the cancer the symptoms resemble those of diseases such as pneumonia). The prognosis for a patient undergoing treatment at this point (mature stage) is usually less than a year.

Before treatment, the patient requires a doctor’s evaluation in order to determine which of the three treatments are suitable for him/her. Details such as age, weight, medical history, and general well-being are considered prior to the commencement of treatment. So, how do you treat pericardial mesothelioma ?

Radiation - As with all cancer treatments that use this method, large doses of radiation are used to kill the cancerous cells on the pericardium. The downside to radiation treatment is that not only are you killing off the cancerous cells, but you are also damaging the vital organs in close proximity to the heart, namely the lungs. The heart also gets damaged (due to the large doses of radiation).

Surgery – We can break this down into two parts; aggressive surgery and palliative procedures. Aggressive surgery involves the removal of the cancerous cell. Since these are very close to the heart and lungs, this makes it an extremely precarious procedure and one that requires an extremely skilled surgeon.
Palliative procedures are used in the latest of stages of pericardial mesothelioma and serve the sole purpose of reducing the symptoms. Usually at this stage the cancer is practically incurable.

Chemotherapy – This is the most widely-used of cancer therapies which involves the use of drugs to kill the cancerous cells. Unfortunately, the majority of drugs used have a low success rate with pericardial mesothelioma. Research is being conducted to come up with a cocktail of drugs that have a more favourable outcome.

There does exist another form of treatment which involves using all three aforementioned treatment options. It is known as Dual Therapy. Surgery is used to remove the cancerous cells, then chemotherapy and radiation are used to kill the remaining cells. The success rate for this method is higher than just using radiation, surgery or chemotherapy alone, but can still be dangerous.

Summary:
Learn about the different treatment options for pericardial mesothelioma.

10 Options in Treating Mesothelioma

As with any cancer, treatment for Mesothelioma depends on the location of the cancer, the progression of the disease, the age as well as state of health of the patient.

It is the oncologist who specializes in the disease who will decide on the line of treatment. The disease is difficult to treat and in most cases the prognosis is poor.

Treatment options include:

1. If the diagnosis is done in the early stages surgery may be recommended to remove all cancerous tissues. This means thoracoscopy, VATS or video assisted thoracic surgery, mediastinoscopy (used for staging), or laproscopy. Often, doctors will advise palliative procedures like chest tube drainage and pleurodesis, thoracoscopy and pleurodesis, pleuroperitonial shunt, or pleurectomy, which treat the symptoms of mesothelioma rather than the disease.
2. Radiation is prescribed aggressively for mesothelioma patients and is often given in combination with surgery or in order to control symptoms, palliatively. Research on using radiation therapy using implants or UV light therapy is in progress as traditional radiation therapy damages surrounding healthy tissue.
3. Chemotherapy is an option and around 12-20% of patients respond to the drugs. Anti-cancer drugs destroy cancer cells and prevent their spread. In mesothelioma, chemotherapy is not considered to be curative. The aim is to prevent spread of the disease; shrink the tumor prior to surgery, known as neoadjuvant therapy; to annihilate any remains of the tumor in the body post surgery; and to relieve pain and other discomfort, palliative chemotherapy. Experts recommend prescribing premetrexed along with cisplastin. These drugs have shown positive results and this is now standard care for Mesothelioma not treatable by surgery.
4. Biological therapy using interleukin 2.
5. Immunotherapy where the body’s own immune system is stimulated to fight the disease. Biological response modifiers, BRMs, are used in treatment. These enhance the functions of the immune system; regulate metabolic reactions that promote growth of cancers; alter cancer cell division; block or reverse processes that lead to formation of cancers; and prevent spread of cancer.
6. Gene therapy, where attempts are made to correct the gene sequence that causes the cancer. This is of two kinds, replacement gene therapy and knockout gene therapy.
7. Administration of lovastatin, a cholesterol lowering drug.
8. Photodynamic treatment where a photosensitive medication is activated using a laser. This is done during the surgical removal of cancerous tissues.
9. Draining of fluid in the chest or abdominal cavity followed by introduction of medications into the cavity to prevent fluid accumulation is done for patients who have uncontrolled fluid accumulation and intense discomfort stemming from it.
10. Combination therapy or Trimodal therapy which means surgery accompanied by radiation and chemotherapy.

Often, complementary medicines are also used. Termed to be holistic this kind of treatment focuses on a patient’s physical, mental, emotional, and spiritual well being.

In the case of Mesothelioma which is untreatable one can opt for clinical trials of new treatments that are in progress in several research laboratories and centers. The best advice on the line of treatment would be that recommended by the oncologist or physician.

Summary:
As with any cancer, treatment for Mesothelioma depends on the location of the cancer, the progression of the disease, the age as well as state of health of the patient.